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直播預告|哈爾濱工業大學、北卡州立大學等專家報告
原文地址：http://news.sciencenet.cn/htmlnews/2024/3/518726.shtm
直播時間：2024年3月8日（周五）20:00-21:30
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北京時間2024年3月8日晚八點，恰逢婦女節，iCANX Talks 第176期邀請到了哈爾濱工業大學田艷紅教授，北卡羅來納州立大學Veronica Augustyn教授，天津大學劉秀云教授、美國加州大學圣地亞哥分校石玲燕教授進行分享，澳大利亞國立大學Lan Fu教授，北京大學張海霞教授擔任主持人，我們誠摯地邀請您加入這場知識的盛宴。
【嘉賓介紹】
Yanhong Tian
哈爾濱工業大學
Micro-Nano Scale Interconnection Builds Bridges from Chips to Devices
【Abstract】
Electronic products are developing towards miniaturization, versatility, low power dissipation, high bandwidth, high speed, and high frequency. The demand for high density advanced packaging is increasingly strong, and the advanced packaging has been applied to important fields such as 5G, aviation, aerospace, and AI. Micro-nano interconnection is a key process in chip packaging, serving as a bridge from chips to components and systems, playing a role in electrical interconnection, mechanical fixation, and environmental protection. Every advancement in advanced chip packaging technology benefits from the development of micro-nano interconnection technology. This report will first introduce interconnection technologies in advanced packages including three-dimensional system packages and chiplets packages. Secondly, the life assessment methods of electronic packaging interconnection will be introduced, including multiple scale modeling and life assessment methods.Finally, a brief introduction will be given to the emerging cutting-edge fields of flexible electronics, including the Nano-joining and printing methods during the fabrication of flexible sensors, including OLED, electrochromic devices and zinc ion battery.
電子產品不斷朝著小型化、多功能化、低功耗、高帶寬和高速高頻方向發展，對高密度先進封裝器件的需求日益強烈，已經應用到5G通信、航空、航天、人工智能AI等重要領域。微納互連是芯片封裝中不可或缺的關鍵工藝，是實現從芯片到元器件及系統的橋梁，起到電氣互連、機械固定和環境保護的作用，先進芯片封裝技術的每一次進步都得益于微納互連技術的發展。演講將介紹先進芯片封裝中的材料、封裝方法和可靠性，包括三維系統級封裝System in Pacakge(SiP)和多芯粒封裝（Chiplets）中的梯度互連材料設計、跨尺度三維互連方法以及多尺度仿真可靠性評價策略和壽命預測模型，最后介紹通過納米尺度連接和打印實現柔性可穿戴電子器件的制備和應用，包括柔性OLED、電致變色器件以及水性鋅離子電池等。
【BIOGRAPHY】
Yanhong Tian, Tenured professor of the School of Materials Science and Engineering in Harbin Institute of Technology, National high-level talents of MOE, Excellent Youth of NSFC in, is currently the vice director of the State Key Laboratory of Advanced Welding and Joining. She mainly engaged in electronic packaging technology and reliabilityand flexible electronic wearable sensor components. She is responsible for key projects of the National NSFC, MOST and MIIT, as well as multiple industry cooperation projects. The research results have been applied to key device packaging in the fields of aerospace electronics, power electronics, and flexible electronics. The research results in the reliability and life assessment of electronic packaging technology have been applied to satellite platform equipment, which ensure the reliable service of domestic electronic devices in severe environments. She served as the chairwoman of the Emerging micro-nano processing technology of the International Institute of Welding (IIW), Co-chair of the Technical Committee of the International Conference on Electronic Packaging Technology (IEEE-ICEPT), Executive Director of the welding branch of the Chinese Mechanical Engineering Society, and editorial board member of multiple academic journals such as Electron. She has published over 300 papers in renowned academic journals and top-level academic conferences, she is the editor or co-editor of six books, and won 4 provincial and ministerial level awards of science and technology.
田艷紅，哈爾濱工業大學長聘二級教授，曾任材料科學與工程學院焊接技術與工程系主任，先進焊接與連接國家重點實驗室副主任。主要從事電子封裝技術與可靠性、第三代半導體封裝、柔性電子可穿戴傳感器件方面的研究。負責專項課題以及多項行業合作項目，研究成果應用到宇航電子、功率電子、柔性電子領域的關鍵器件封裝中，在電子封裝技術可靠性及壽命評估方面的研究成果應用于多個型號衛星平臺電子裝備中，保障了國產核心電子器件在復雜服役環境下的可靠運行。擔任國際焊接學會(IIW)新興微納連接工藝分會主席、電子封裝技術國際會議(IEEE-ICEPT)技術委員會共同主席、中國機械工程學會焊接分會常務理事以及Electron等多個學術期刊的編委。在Adv. Mater, Matter, Cell子刊，ACS Nano, Adv.Opt.Mater., JMST等國內外知名學術期刊及國際頂級學術會議上發表論文300余篇，授權專利40余項，主編及參編著作6部，獲得省部級科技獎勵4項。
Veronica Augustyn
北卡羅來納州立大學
Harnessing Proton-coupled Electrochemical Processes in Metal Oxides for Energy Storage and Conversion
【Abstract】
The electrochemical behavior of protons is important for advancing energy storage and conversion technologies operating in aqueous electrolytes. In this presentation, I will discuss our group’s research in understanding the behavior of protons in transition metal oxides, which include: proton adsorption and insertion (relevant for energy storage), hydrogen evolution (relevant for energy conversion), and dissolution of the transition metal oxide due to proton adsorption (considered a parasitic process). Of particular interest are systems where these processes can co-exist. I will also discuss our solid state chemistry approach to tuning the interlayer environment of hydrous oxides in order to control their electrochemical behavior in aqueous electrolytes. Overall, this research provides fundamental understanding of electrochemical processes of importance for aqueous energy and environmental technologies.
質子的電化學行為對于推進在水性電解質中運行的能量存儲和轉換技術非常重要。在本報告中，Veronica Augustyn將討論我們小組在了解過渡金屬氧化物中質子行為方面的研究，其中包括：質子吸附和插入（與能量存儲相關）、氫演化（與能量轉換相關）以及過渡金屬氧化物因質子吸附而溶解（被視為寄生過程），尤其是這些過程可以共存的系統。Veronica Augustyn還將討論調諧含水氧化物層間環境的固態化學方法，以控制它們在水性電解質中的電化學行為。總之，這項研究為水性能源和環境技術中重要的電化學過程提供了基本認識。
【BIOGRAPHY】
Professor Veronica Augustyn is the Jake & Jennifer Hooks Distinguished Scholar in Materials Science & Engineering, University Faculty Scholar, and Associate Professor at North Carolina State University. She also serves as an Associate Editor for the Journal of Materials Chemistry A and Materials Advances. Her research group focuses on the design, synthesis, and mechanistic understanding of materials for electrochemical energy and environmental technologies. She also leads an award-winning international project at NC State, SciBridge, which develops renewable energy research and education collaborations between universities in Africa and the U.S. Her research group has been recognized with a 2019 Sloan Fellowship in Chemistry, a 2019 DOE Early Career Award, and a 2017 NSF CAREER Award. In 2021, she was recognized by NC State as a Goodnight Early Career Innovator and received the George H. Blessis Advising Award for her mentorship of undergraduate students.
維羅妮卡-奧古斯汀教授是北卡羅來納州立大學材料科學與工程系杰克和詹妮弗-胡克斯杰出學者、大學教師學者和副教授。她還是《材料化學雜志》（Journal of Materials Chemistry A）和《材料進展》（Materials Advances）的副主編。她的研究小組專注于電化學能源和環境技術材料的設計、合成和機理理解。她還領導著北卡羅來納州立大學的一個獲獎國際項目--SciBridge，該項目旨在發展非洲和美國大學之間的可再生能源研究和教育合作。她的研究小組曾獲得2019年斯隆化學獎學金、2019年能源部早期職業生涯獎和2017年國家自然科學基金CAREER獎。2021 年，她被北卡羅來納州立大學評為 Goodnight Early Career Innovator，并因指導本科生而獲得 George H. Blessis Advising Award。
Xiuyun Liu
天津大學
New Advances in Brain Disease Diagnosis and Treatments in NICU
【ABSTRACT】
Multi-modality monitoring becomes extremely important in intensive care unit for clinical diagnosis and treatments, especially in brain diseases. In neuro intensive care unit (NICU), various tools are applied at bedside, including intracranial pressure monitor, transcranial cerebral blood flow monitor, brain oxygen saturation monitor, brain metabolic monitor, etc. Dr Liu’s research mainly focuses on developing new techniques for clinicians in NICU. In this talk, she will introduce their new research achievements in brain disease diagnosis and treatments, including the application of AI, physiological signal processing algorithms and non-invasive stimulations, etc.
近年來，隨著腦疾病患病人數的不斷增多，疾病的診斷與治療受到了越來越多的關注。重癥多模態監測，如顱內壓、腦氧、腦血流、腦電等的監測，對于腦疾病的診斷十分重要，劉博士的科研工作聚焦麻醉與重癥醫學領域的醫工結合研究工作，旨在解決當前麻醉重癥遇到的工程瓶頸問題，為一線醫生提供更精準的治療手段及策略。本次報告中，她講介紹最近在腦疾病診療方面的最新成果，內容涉及AI，生理電信分析，無創刺激等。
【BIOGRAPHY】
Xiuyun Liu is currently a professor in Biomedical Engineering at Tianjin University, China. She got her PhD in Clinical Neurosciences from University of Cambridge in 2017, after which, she went to University of California, San Francisco (UCSF) to do her first postdoc in Physiological Nursing Department between the year of 2017 and 2019. Then she joined the Department of Critical Care Medicine and Anesthesiology, Johns Hopkins University to do her research from 2019 to 2021. She joined Tianjin University as a full professor in July, 2021, and is currently serving as the vice dean of medical college. Her research work mainly focuses on developing various biomedical engineering technologies, such as photoacoustic imaging, non-invasive intracranial pressure monitoring etc into critical care medical field. She got Bill Gates Scholarship for her PhD study at Cambridge, which is the top full scholarship at Cambridge. She also obtained the Chinese Government Award for Outstanding Self-financed Students Abroad in 2016. She is the vice president of the Life Support Technology Branch of the Chinese Medical Rescue Association, a member of the standing committee of China Anesthesia and Perioperative Medicine Branch, a member of the standing committee of Tianjin Neuroscience Society, and the editorial board member of Military Medical Research.
劉秀云，天津大學英才教授，博士生導師，醫學院副院長、先進醫用材料與醫療器械全國重點實驗室副主任，神經重癥教育部醫藥基礎研究創新中心執行主任。博士畢業于劍橋大學臨床神經科學專業，后于加州大學舊金山分校及約翰霍普金斯大學麻醉重癥系從事博士后研究，2021年入職天津大學。擔任美國重癥麻醉師協會學術委員會（SOCCA）委員、中國生物醫學工程學會理事、傳感器分會副主委，中國醫學救援協會生命支持技術分會副會長、CAMDI麻醉與圍術期醫學分會委員、天津市神經科學學會第六屆理事會常務理事，Military Medical Research青年編委等學術職務。入選《麻省理工科技評論》35歲以下科技創新35人（亞太區）。聚焦麻醉與重癥醫學領域的醫工結合研究工作，旨在解決當前麻醉重癥遇到的工程瓶頸問題，為一線醫生提供更精準的治療手段及策略。
Lingyan Shi
美國加州大學圣地亞哥分校
Multimolecular Hyperspectral Metabolic Imaging in Aging and Diseases
【ABSTRACT】
Metabolism is a complex biochemical process in living organisms that involves different biomolecules and consists of various reaction steps. To understand the multi-step biochemical reactions involving various components, its essential to elucidate in-situ dynamics and the correlations between different types of biomolecules at subcellular resolution. In this context, we integrated deuterium-probed pico-second stimulated Raman Scattering (DO-SRS), multiphoton fluorescence (MPF), and second harmonic generation (SHG) into a single microscopy system to study metabolic changes in aging and diseases.
Our current multimodal microscopy becomes a super-resolution (59nm) hyperspectral multiplex imaging platform by developing A-PoD and PRM deconvolution algorithms. Combining with deuterated molecules (glucose, amino acids, fatty acids, water molecules etc.) as probes, the metabolic heterogeneity of brain, adipose, liver, muscle, retina, kidney, lung, and ovaries, etc. (in Human, Mouse, and Drosophila tissues) are quantitatively imaged. This multi-molecular super resolution imaging approach dissects the molecular events and cellular machinery in living organisms during aging and disease progression, offering powerful tools potentially for disease detection, diagnosis, and assessing therapeutic efficacy & resistance, as well as for mechanistic understanding of scientific fundamentals in neurodegenerative diseases, cancer, drug delivery, and aging processes.
新陳代謝是生物體內的復雜生化過程，涉及不同的生物分子，并包括各種反應步驟。為了理解涉及不同成分的多步生化反應，必須闡明原位動態和亞細胞分辨率下不同類型生物分子之間的相關性。在這種背景下，我們將氘探測的皮秒激發拉曼散射（DO-SRS）、多光子熒光（MPF）和二次諧波生成（SHG）集成到單一顯微系統中，以研究衰老和疾病中的早期新陳代謝變化。
我們當前的多模態顯微鏡通過開發A-PoD和PRM去卷積算法，成為了一個超分辨率（59納米）高光譜多重成像平臺。結合氘代分子（葡萄糖、氨基酸、脂肪酸、水分子等）作為探針，對大腦、脂肪、肝臟、肌肉、視網膜、腎臟、肺部和卵巢等（人類、小鼠和果蠅組織）的代謝異質性進行定量成像。這種多分子超分辨率成像方法解剖了生物體內在衰老和疾病進展過程中的分子事件和細胞機制，為疾病檢測、診斷和評估治療效果和抗藥性提供了強大的工具，同時也為神經退行性疾病、癌癥、藥物輸送和衰老過程的科學基礎機制的理解提供了可能。
【BIOGRAPHY】
Lingyan Shi is currently an Assistant Professor in the Department of Bioengineering at UC San Diego. Her Lab’s research focuses on developing high-resolution, high-speed multimodal microscopy and for studying metabolic dynamics in aging and diseases. She discovered the "Golden Window" for deep tissue imaging and developed metabolic imaging platforms including “DO-SRS” and “STRIDE”. Shi group at UC San Diego transformed SRS into a super-resolution multiplex microscopy using A-PoD and PRM algorithms, uncovering lipid metabolic dynamics in the brain and fat tissues during aging processes. Dr. Shi holds 8 awarded patents. She received the Blavatnik Regional Award for Young Scientist in 2018, the Hellman Fellowship Award in 2021-2022, the "Rising Star Award" from Nature Light Science & Applications in 2021, the “Advancing Bioimaging Scialog Fellow" by RCSA and CZI, the “David L. William Lecture & Scholarship” Award from the Kern Lipid Conference, and the “Sloan Research Fellow” Award in Chemistry in 2023, and the 2024 rising star award by BMES-Cell and Molecular Bioengineering (CMBE) society.
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